FAANG
From 2015-10-30 to 2019-10-29, running COST action
The most significant challenge in the post-genomic era is connecting genotype to quantitative phenotype in basic and applied biology - the genome to phenome challenge.
Significant progress has been made in associating sequence variation with quantitative phenotypes motivated by the importance of animals as food sources, models for human health, and key ecological actors. In domesticated animals, the wealth of phenotypic diversity of different breeds and populations and decades of research have been key to such progress, and coupled with advances in sequencing the genomes of these species provides unique opportunities to study genome-phenome relationships.
FAANG (Functional Annotation of ANimal Genomes - A coordinated international action to accelerate genome to phenome) has been created as we all recognise the importance of coordinating this effort to maximize efficiency and data quality as demonstrated by the ENCODE project.
FAANG aims to deliver standardized datasets from a limited set of individuals representing species which have reference quality draft genome assemblies and substantial publicly available phenotypic datasets.
The FAANG project will establish an infrastructure capable of efficiently analyzing genome-wide functional data for animal species. Such large-scale analyses will contribute to our understanding of how variation in gene sequences and functional components determine phenotypic diversity. This understanding will inform the development and exploitation of improved models for predicting complex phenotypes from sequence information.
The most significant challenge in the post-genomic era is connecting genotype to quantitative phenotype in basic and applied biology - the genome to phenome challenge.
Significant progress has been made in associating sequence variation with quantitative phenotypes motivated by the importance of animals as food sources, models for human health, and key ecological actors. In domesticated animals, the wealth of phenotypic diversity of different breeds and populations and decades of research have been key to such progress, and coupled with advances in sequencing the genomes of these species provides unique opportunities to study genome-phenome relationships.
FAANG (Functional Annotation of ANimal Genomes - A coordinated international action to accelerate genome to phenome) has been created as we all recognise the importance of coordinating this effort to maximize efficiency and data quality as demonstrated by the ENCODE project.
FAANG aims to deliver standardized datasets from a limited set of individuals representing species which have reference quality draft genome assemblies and substantial publicly available phenotypic datasets.
The FAANG project will establish an infrastructure capable of efficiently analyzing genome-wide functional data for animal species. Such large-scale analyses will contribute to our understanding of how variation in gene sequences and functional components determine phenotypic diversity. This understanding will inform the development and exploitation of improved models for predicting complex phenotypes from sequence information.