Pro-Ovum
From 2012-02-01 to 2016-01-31, ongoing project
Infertility is a major problem that affects domestic mammals and declining fertility represents an obstacle in maintaining profitability of dairy farms in Europe and worldwide. Since declining fertility of cattle is mainly due to the poor quality of the oocytes, defining the factors and mechanisms that affect oocyte quality, is essential for improving female fertility. In particular, basic knowledge of which proteins within the oocyte regulate meiosis, oocyte fertilizability and early embryonic development would be advantageous.
The Aim of the PRO-OVUM project is to test the hypothesis that Progesterone Receptor Membrane Component 1 (PGRMC1) is one of the key factors that regulate mammalian oocyte quality and therefore female fertility. This hypothesis is based on preliminary data that suggest that PGRMC1 is likely to play an essential role in chromosomal segregation, which occurs during oocyte maturation.
This hypothesis will be rigorously tested by determining 1) whether PGRMC1 plays an essential role in maintaining the ability of bovine oocytes to complete meiosis, undergo fertilization and develop to an healthy embryo in vitro, by genetically manipulating the levels of PGRMC1 within the oocyte, and 2) PGRMC1’s mechanism of action by identifying its interacting proteins within the oocyte.
For more information, Pro-Ovum or http://cordis.europa.eu/project/rcn/102300_en.html.
Coordinator:
UNIVERSITA DEGLI STUDI DI MILANO
The Aim of the PRO-OVUM project is to test the hypothesis that Progesterone Receptor Membrane Component 1 (PGRMC1) is one of the key factors that regulate mammalian oocyte quality and therefore female fertility. This hypothesis is based on preliminary data that suggest that PGRMC1 is likely to play an essential role in chromosomal segregation, which occurs during oocyte maturation.
This hypothesis will be rigorously tested by determining 1) whether PGRMC1 plays an essential role in maintaining the ability of bovine oocytes to complete meiosis, undergo fertilization and develop to an healthy embryo in vitro, by genetically manipulating the levels of PGRMC1 within the oocyte, and 2) PGRMC1’s mechanism of action by identifying its interacting proteins within the oocyte.
For more information, Pro-Ovum or http://cordis.europa.eu/project/rcn/102300_en.html.
Coordinator:
UNIVERSITA DEGLI STUDI DI MILANO